谁能帮忙把下面的中文翻译成专业点的英文 跪求p16主要功能是: 在细胞增殖的整个关键环节上对细胞分裂和生长进行适当抑制, 使细胞按正常程序性周期分裂、生长和死亡, 防止细胞生长分裂
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谁能帮忙把下面的中文翻译成专业点的英文 跪求p16主要功能是: 在细胞增殖的整个关键环节上对细胞分裂和生长进行适当抑制, 使细胞按正常程序性周期分裂、生长和死亡, 防止细胞生长分裂
谁能帮忙把下面的中文翻译成专业点的英文 跪求
p16主要功能是: 在细胞增殖的整个关键环节上对细胞分裂和生长进行适当抑制, 使细胞按正常程序性周期分裂、生长和死亡, 防止细胞生长分裂失控,最终向肿瘤发展和转化[4].在细胞增值调控过程中p16蛋白与cycinD1竞争性的与CDK4结合,从而抑制CDK4的激酶活性,使下游调控的Rb蛋白处于脱磷酸化状态,从而阻断细胞从G1期向S期的转化.抑制细胞增殖,相反当p16基因缺失或突变时,p16蛋白不表达或表达量下调,那么cycinD1与CDK4的结合占优势,过度刺激细胞分裂,导致细胞增值失控.最终形成肿瘤[5].对细胞周期的研究发现[6],在G1→S期转换的过程中,活化的cyclinD/CDK复合物的活性逐渐消失,Rb蛋白被磷酸化而失活,当细胞进入S期后,此时p16蛋白表达量达到峰值.与Rb蛋白结合到一起的E2F转录因子被释放,启动与增值有关的基因的转录从而反过来抑制cyclinD/CDK4 激酶的活性.
别用现成的软件直接翻译好吧,非诚勿扰,谢谢
谁能帮忙把下面的中文翻译成专业点的英文 跪求p16主要功能是: 在细胞增殖的整个关键环节上对细胞分裂和生长进行适当抑制, 使细胞按正常程序性周期分裂、生长和死亡, 防止细胞生长分裂
P16 main function is: on the key link of cell proliferation inhibition of cell division and growth properly, make according to normal procedural cycle division, growth and cell death, prevent split cells to grow out of control, eventually to tumor development and transformation of [4].P16 protein in the process of cell proliferation regulation combined with cycinD1 competitive and CDK4, thus inhibiting CDK4 kinase activity, make the regulation of the downstream Rb protein in the phosphorylation state, thereby blocking from G1 phase to S phase cell transformation.Inhibition of cell proliferation, on the contrary when p16 gene deletions or mutation, p16 protein expression does not express or the quantity, so the combination of cycinD1 and CDK4 predominates, excessive stimulation of cell division, leading to cell proliferation is out of control.Eventually form tumor [5].Study found [6] of the cell cycle in G1 to S phase transition process, the activity of activated cyclinD/CDK complex gradually disappear, Rb protein phosphorylation and inactivation, when cells into S phase, the peak amount of p16 protein expression.And Rb protein release of E2F transcription factors together, start with appreciation of gene transcription and, in turn, inhibit cyclinD/CDK4 kinase activity.