what is wrong with you和what’s up with you有什么区别?（ ）,Tom?-I can’t find my bike.括号里面填哪个

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what is wrong with you和what’s up with you有什么区别?（ ）,Tom?-I can’t find my bike.括号里面填哪个
what is wrong with you和what’s up with you有什么区别?
（ ）,Tom?
-I can’t find my bike.
括号里面填哪个

what is wrong with you和what’s up with you有什么区别?（ ）,Tom?-I can’t find my bike.括号里面填哪个
选第一个
what is wrong with you
这个,符合语境,意思是：
怎么了,汤姆?
我找不到我的自行车了.
而 第二个,what's up with you
更多 是用在打招呼,你怎么样了?
例如：Hey,what's up with you,Tom?
Don't mention it.I just lose my bike.
[ 汤姆,你还好吗?
别提了,我丢了我的自行车.]

填 what is wrong with you
what is wrong with you 意思是 你有什么事 你有什么不舒服 你有什么为难的地方 总之都是不好的事
what’s up with you 是你最近怎么样 打招呼用的

what's wrong with you

what is wrong with you? 问有什麼问题
what’s up with you？打招呼用，你怎麼样？
所以用what is wrong with you

翻译过来没什么区别，只是wrong是正式用语，而up是俚语，通常寒暄时说up。
这道题如果非要做个选择的话，那选前者。

填what's up with u发生了什么事？
what's wrong with u经常用来问别人是否生病之类的

第二个

What's up with you

SO WHAT IS WRONG WITH 翻译：what is wrong with you? What the hell is wrong with you? What is wrong with you的中文 what is wrong with you同义句 what is wrong with you 答句 用英文翻译: What is wrong with you? What the hell is wrong with me What is wrong with?谁知道啊 What is wrong with you?如何回答 what is wrong with you 如题 What is wrong with you?同义句 What is wrong with the kite?谢 what is the matter?what is wrong with celetis 是What is the wrong with you还是What is wrong with you? What is wrong with you?(近义句）急!What is wrong with you?(近义句） 是What is the wrong with you还是What is the wrong with you? The teacher asked __ yesterdayA what is wrong with himB What was wrong with himC what wrong with him isD what wrong with him was